HEB Spring 2026 Colloquium Series: Dr. Jonathan H. Epstein

Dr. Jonathan H. Epstein, a veterinarian and epidemiologist, is a global leader in developing strategic partnerships among government, private sector, NGO and academic research institutions. For over 25 years, he has applied an evidence-based, multidisciplinary approach to research and policy partnerships with US government agencies, such as the CDC, USDA, USFWS, and USGS National Wildlife Health Center, universities, and foreign agencies under ministries of Health, Agriculture and Environment in more than 40 countries across Asia, Africa, and the Americas. As a consultant, he helps develop systems that strengthen disease surveillance and response, prevent the spillover and emergence of zoonotic diseases and protect human and animal health.

Talk Title:

Ecological and evolutionary drivers of zoonotic virus spillover and emergence

Abstract:

Spillover of zoonotic viruses from wildlife into livestock and humans is largely driven by human activities that modify natural systems in ways that increase contact with wildlife. Infectious disease surveillance systems are frequently designed to identify human cases once they’ve been admitted to a hospital. As a result, index cases and asymptomatic cases are often missed, making it difficult to identify mechanisms of spillover. Understanding evolutionary principles, the pathways by which zoonotic pathogens infect livestock and people, and measuring the frequency of exposure is essential for developing effective interventions that reduce the risk of viral spillover and disease emergence. Here we will discuss the drivers of viral spillover and focus on Nipah virus to illustrate a multidisciplinary approach that has helped characterize viral circulation, spillover risk, and develop interventions. We will also discuss current gaps in knowledge as outbreaks continue to occur in India and Bangladesh.